Exploring selectivity requirements for peripheral versus central benzodiazepine receptor bindingaffinity: QSAR modeling of 2-phenylimidazo[1,2-a]pyridine acetamides using topological and physicochemical descriptors

Abstract

<span style="mso-bidi-language:HI">Considering the potential of peripheral benzodiazepine receptor (PBR) Jigands in therapeutic applications and clinical benefit in the management of a large spectrum of different indications, quantitative structure-activity relationship (QSAR)

<span style="mso-bidi-language:HI">study has been attempted to explore the structural and physicochemical requirements for selectivity of 2-phenylimidazo[1,2- a]pyridineacetamides for binding with peripheral over central benzodiazepine receptors (CBRs). For PBR binding affinity,

<span style="mso-bidi-language:HI">molar refractivity (<i>MR</i>)<i> </i>shows a parabolic relation with binding affinity suggesting that binding affinity increases with increase in volume of the compounds, until it reaches the critical value, after which the affinity decreases. …

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