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http://nopr.niscpr.res.in/handle/123456789/30500| Title: | Regulation of N-Myristoyltransferase by the Calpain and Caspase Systems |
| Authors: | Sharma, Rajendra K Kumar, Sujeet Parameswaran, Sreejit Dimmock, Jonathan R |
| Keywords: | Myristoylation;N-myristoyltransferase;Calpain;Caspase;Cancer |
| Issue Date: | Dec-2014 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems. |
| Page(s): | 506-511 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.51(6) [December 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 51(6) 506-511.pdf | 203.7 kB | Adobe PDF | View/Open |
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