Synthesis of pyrazolines, isoxazolines and aminopyrimidines as biological potent agents

Abstract

<span style="mso-bidi-language:HI">Chalcones, 2-phenylamino-4-(4'-fluorophenylamino )-6-[4'-{3"-(phenyl/substituted phenyl/2"'- furanyl/3'"-pyridinyl)-2"- propenon-1<span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">"-y1} <span style="mso-bidi-language: HI">phenylamino]-<i>s</i>-triazines <b>6a-j </b>have been prepared from ketone <b>5</b> based on <i>s</i>-triazine nucleus. These chalcones <b>6a-j</b> on cyclisation with hydrazine hydrate, hydroxylamine hydrochloride and guanidine nitrate give the corresponding pyrazolines <b>7a-j</b>, isoxazolines <b>8a-j</b> and

<span style="mso-bidi-language:HI">aminopyrirnidines <b>9a-j</b>, respectively. Antimicrobial activities of all synthesized compounds have been performed by using cup-plate method against bacteria and by using poisoned food technique against fungi. The constitutions of newly synthesized

<span style="mso-bidi-language:HI">compounds have been established on the basis of elemental analysis, IR and ^{<span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">1</span>}<span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">H <span style="mso-bidi-language:HI">NMR spectral data.

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