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http://nopr.niscpr.res.in/handle/123456789/30691| Title: | Cytotoxic ent-kaurane diterpenoids from Isodon racemosa (Hemsl) Hara |
| Authors: | Ding, Lan Liu, Guo-An Wang, Lai |
| Keywords: | Isodon racemosa (Hemsl) Hara;Ent-kaurane diterpenoid;Racemosin A;Cytotoxicity |
| Issue Date: | Feb-2006 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.7 C 07 C II A 61 K 35/00 |
| Abstract: | A new ent-kaurane diterpenoid racemosin A (1) and three known compounds, leukamenin E (2), glaucocalyxin A (3) and wangzaozin A (4), have been isolated from the leaves of Isodon racemosa (Hemsl) Hara. The new diterpenoid is identified as 14β-hydroxy-3β, 7α-acetoxy-ent-kaur-16-en-15-one on the basis of spectral data, especially by 2D NMR techniques. Compounds 1-4 show significant cytotoxic activity against Bel-7402 and HO-89! 0 cells in the range of 1.51-2.57 and 3.33-4.02 µg/mL, respectively. This may be due to the presence of conjugated exo-methylene systen in an ent-kaurane skeleton. |
| Page(s): | 548-551 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.45B(02) [February 2006] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 45B(2) 548-551.pdf | 792.49 kB | Adobe PDF | View/Open |
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