<span style="mso-bidi-language:HI">QSAR studies of 2,3-diarylpyrazolo[1<b><i><span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">,</span></i></b><span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">5-<i>b</i>]<b><i>-</i></b><span style="mso-bidi-language:HI">pyridazine analogs as cyclooxygenase-2 inhibitors </span></span></span>

Abstract

<span style="mso-bidi-language:HI">Cyclooxygenase-2 inhibitors arc of current interest, because these alleviate inflammation, fever, pain, rheumatic and osteoarthritis without side effects, produced by classical NSAlDs. QSAR analysis helps in exploring molecular insight, which are

<span style="mso-bidi-language:HI">responsible for drug-receptor interactions. QSAR studies have been performed on a series of some 2,3-diaryl-pyrazolo[1,5-<i>b</i>)pyridazine analogs as COX-2 inhibitors using substituent constant in lead structure for 2D and physicochemical properties

<span style="mso-bidi-language:HI">of molecules for 3D-QSAR analysis respectively. The correlations have been established using regression analysis techniques. 2D-QSAR analysis study has revealed that the substitution of hydrophobic group in the 2,3-diaryl-pyrazolo[1<i><span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">,</span></i><span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">5-<i>b</i><span style="mso-bidi-language:HI">)pyridazines at R₂ position is favourable while substitution of bulkier group at R₂

<span style="mso-bidi-language:HI">position is unfavourable for COX-2 inhibitory activity. In 3D-model, Morl4u and Mor29v are 3D-MoRSE code have been calculated by summing atom weights which have been viewed by a different angular scattering function contributed positively to

<span style="mso-bidi-language:HI">COX-2 inhibitory activity. G (O..O) is a conformational dependent descriptor based on the geometry of the molecule contributed negatively to COX-2 inhibitory activity.

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