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http://nopr.niscpr.res.in/handle/123456789/30750Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jha, Amitabh | - |
| dc.contributor.author | Duffield, Katherine M | - |
| dc.date.accessioned | 2015-03-03T11:51:50Z | - |
| dc.date.available | 2015-03-03T11:51:50Z | - |
| dc.date.issued | 2006-10 | - |
| dc.identifier.issn | 0975-0983(Online); 0376-4699(Print) | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/30750 | - |
| dc.description | 2313-2320 | en_US |
| dc.description.abstract | 3,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus of the current research has been to tine tune the biological activity of these compounds by rational alteration of substituents on this pharmacophore to increase potency and selectivity. These compounds arc presumed to bc devoid of gcnctoxicity and act by selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have been reviewed here with emphasis on their chemistry, cytoxicity and quantitative structure-activity relationship studies. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.relation.ispartofseries | Int. Cl.8 C07D | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJC-B Vol.45B(10) [October 2006] | en_US |
| dc.subject | Piperidone derivatives | en_US |
| dc.subject | Anticancer agents | en_US |
| dc.subject | Cytotoxic | en_US |
| dc.subject | Thiolation | en_US |
| dc.subject | Topoisomerase II | en_US |
| dc.subject | Green chemistry | en_US |
| dc.title | 3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJC-B Vol.45B(10) [October 2006] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 45B(10) 2313-2320.pdf | 1.87 MB | Adobe PDF | View/Open |
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