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http://nopr.niscpr.res.in/handle/123456789/30930| Title: | Synthesis of novel spiro[indole-pyranoimidazole] and spiro [indole-pyranopyrrole] derivatives |
| Authors: | Dandia, Anshu Taneja, Harshita Saha, Mitali |
| Issue Date: | Sep-1997 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An elegant one-step synthesis of two novel spiro ring systems viz., spiro [3H-indole-3,4'(1’H)-pyrano[2,3-d-imidazol]-2-oxo-2'-thiones-5' carbonitrile (VI) and spiro[3H-indole-3,4'(1’H) pyrano [2,3-c] pyrrole]-5' carbonitrioles (VII) in 44-59% yields is described. The spiro heterocycles were prepared by the Michael reactions of 3-dicyanomethylene-2H-indol-2-ones (III) with I-phenyl-2-thio-hydamoin (IV) and 2-pyrrolidone/N-methyl-2-pyrrolidone (V), respectively, while the intermediate (III) has been synthesized from substituted indole-2,3-diones (I) with malanonitrile (II). The synthesized compounds have been characterized on the basis of elemental analyses IR' 1H NMR 19F NMR and mass spectral studies. All the compounds have been screened in vitro for antifungal activity against Alternaria alternata. |
| Page(s): | 243-246 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Appears in Collections: | IJCT Vol.04(5) [September 1997] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCT 4(5) 243-246.pdf | 732.24 kB | Adobe PDF | View/Open |
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