Effect of ethanolic extract of <i style="mso-bidi-font-style:normal">Coriandrum sativum</i> L. on tacrine induced orofacial dyskinesia

Abstract

The effect of ethanolic extract of <i style="mso-bidi-font-style: normal">Coriandrum sativum</i> L. seeds (100, 200 mg/kg) was studied on tacrine induced orofacial dyskinesia. Tacrine (2.5 mg/kg, i.p.) treated animals were observed for vacuous chewing movements (VCM), tongue protrusions (TP) and orofacial bursts (OB) for 1 h followed by observations for locomotor changes and cognitive dysfunction. Sub-chronic administration of <i style="mso-bidi-font-style: normal">Coriandrum sativum</i> L. seed extract (E-CS) (100, 200 mg/kg, p.o., for 15 days significantly (<i style="mso-bidi-font-style:normal">P</i> <0.05) decreased the tacrine induced VCM, TP and OB; and also significantly (<i style="mso-bidi-font-style:normal">P</i> <0.05), increased locomotion and cognition compared to the tacrine treated group. Biochemical analysis revealed that tacrine administration significantly (<i style="mso-bidi-font-style:normal">P</i> <0.05) decreased the levels of superoxide dismutase (SOD), Catalase (CAT), glutathione reductase (GSH) levels and also significantly (<i style="mso-bidi-font-style:normal">P</i> <0.05) increased lipid peroxidation (LPO) as an index of oxidative stress, whereas sub-chronic administration of E-CS significantly (<i style="mso-bidi-font-style: normal">P</i> <0.05) improved the antioxidant enzyme (i.e. SOD, CAT, and GSH) levels and also significantly (<i style="mso-bidi-font-style:normal">P</i> <0.05) decreased lipid peroxidation (LPO). The results have demonstrated the protective role of ethanolic extract of <i style="mso-bidi-font-style:normal">Coriandrum sativum</i>. L against tacrine induced orofacial dyskinesia.