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http://nopr.niscpr.res.in/handle/123456789/31489| Title: | Synthesis and antibacterial evaluation of novel sulfonamide based [1,2,3]-triazoles |
| Authors: | Batra, Neha Roy, Basabi Mazumder, Sibnath Nath, Mahendra |
| Keywords: | Sulfonamide;[1,2,3]-triazoles;Huisgen [3+2] cycloaddition;Alkynes;Antibacterial activity;MTT assay |
| Issue Date: | May-2015 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A new series of sulfonamide based [1,2,3]-triazoles 4a-i, 5 and 6 has been prepared in 65-99% yield through Huisgen [3+2] cycloaddition reaction of 4-azido-N-substitutedbenzenesulfonamides 2a,b with various alkynes (3a-i or phenyl acetylene) in the presence of CuSO4.5H2O and sodium ascorbate in t-butanol and water (1:1) mixture at 40°C. The structures of all the newly synthesized molecules have been established on the basis of IR, 1H and 13C NMR and high resolution mass spectral analysis. Furthermore, these compounds have been evaluated for their preliminary in vitro antibacterial activity against two Gram-negative bacteria viz. Escherichia coli (MTCC 433) and Salmonella enterica ser. typhi (MTCC 733) and a Gram-positive bacterium viz. Streptococcus mutans (MTCC 497) by using MTT assay. |
| Page(s): | 650-655 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.54B(05) [May 2015] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 54B(5) 650-655.pdf | 91.78 kB | Adobe PDF | View/Open |
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