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http://nopr.niscpr.res.in/handle/123456789/31521| Title: | Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein |
| Authors: | Rahaman, Sayed Modinur Dey, Kuntal Chakraborti, Tapati Chakraborti, Sajal |
| Keywords: | Pulmonary artery smooth muscle cells;Oxidant;Glutathionylation;Na+/K+-ATPase;Na+/K+ATPase inhibitor |
| Issue Date: | Apr-2015 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2.-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity. |
| Page(s): | 119-124 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.52(2) [April 2015] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 52(2) 119-124.pdf | 202.05 kB | Adobe PDF | View/Open |
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