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Title: Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein
Authors: Rahaman, Sayed Modinur
Dey, Kuntal
Chakraborti, Tapati
Chakraborti, Sajal
Keywords: Pulmonary artery smooth muscle cells;Oxidant;Glutathionylation;Na+/K+-ATPase;Na+/K+ATPase inhibitor
Issue Date: Apr-2015
Publisher: NISCAIR-CSIR, India
Abstract: The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2.-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.
Page(s): 119-124
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.52(2) [April 2015]

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