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http://nopr.niscpr.res.in/handle/123456789/31785| Title: | An efficient and straight forward strategy for the synthesis of enantiomerically pure (S)-1-benzyl-5-(alkyl/aryl amino) methyl)-pyrrolidin-2-ones |
| Authors: | Panday, Sharad Kumar Pathak, Manoher Bhushan Prasad, Jagdish |
| Keywords: | Enantiomerically pure;Dysibetaine;4,5-diaminovaleric acid (DAVA);Conformationally restricted PNA analogues;(S)-5-((Alkyl/aryl amino) methyl) pyrrolidin-2-ones |
| Issue Date: | Jul-2015 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A simple, efficient and straightforward strategy for the synthesis of enantiomerically pure (S)-5-((alkyl/aryl amino) methyl)-pyrrolidin-2-ones from N-benzyl-5(S)-pyroglutaminol through Mitsunobu reaction has been described. These pyrrolidin-2-ones have great potential to act as asymmetric precursors for the synthesis of bioactive compounds/ natural products requiring suitably substituted aminomethyl group at C-5 of native pyrrolidin-2-ones. |
| Page(s): | 936-939 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.54B(07) [July 2015] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 54B(7) 936-939.pdf | 112.88 kB | Adobe PDF | View/Open |
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