<span style="font-size:11.0pt;font-family: "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;letter-spacing:-.1pt;mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:HI" lang="EN-GB">Comparative studies on ability of <i style="mso-bidi-font-style: normal">N</i>-acetylated chitooligosaccharides to scaven<span style="font-size:11.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">ge reactive oxygen species and protect DNA from oxidative damage</span></span>

Salgaonkar, Neeta; Prakash, Divya; Nawani, N N; Kapadnis, B P

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/31805

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DC Field	Value	Language
dc.contributor.author	Salgaonkar, Neeta	-
dc.contributor.author	Prakash, Divya	-
dc.contributor.author	Nawani, N N	-
dc.contributor.author	Kapadnis, B P	-
dc.date.accessioned	2015-07-17T09:23:31Z	-
dc.date.available	2015-07-17T09:23:31Z	-
dc.date.issued	2015-04	-
dc.identifier.issn	0975-0967 (Online); 0972-5849 (Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/31805	-
dc.description	186-192	en_US
dc.description.abstract	Antioxidants have key role in scavenging free radicals and have been considered as dietary part of health conscious population for reducing the risk of many diseases. In the present study, commercially available N-acetylated chitooligosaccharides [(GlcNAc)_n; n=2, 3, 5, 6] were studied for their antioxidant ability against superoxide, hydroxyl, DPPH radicals and H₂O₂ by various radical scavenging assays. The N-acetylated chitooligosaccharides exhibited radical scavenging activities in the range of 49.1-63% for hydroxyl radical and 41-53.3% for superoxide radical. Their antioxidant ability was at par or better than standard antioxidants like butylated hydroxyanisole and mannitol. These N-acetylated chitooligosaccharides were also evaluated for their ability to prevent oxidative DNA damage in peripheral blood mononuclear cells exposed to H₂O₂. (GlcNAc)₂, (GlcNAc)_3,(GlcNAc)₅ and (GlcNAc)₆decreased the oxidative DNA damage due to H₂O₂ by 59.5, 55.5, 22.9 and 4.9%, respectively. This antioxidative potential of N-acetylated chitooligosaccharides can be extended to beneficial health applications.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJBT Vol.14(2) [April 2015]	en_US
dc.subject	Antioxidant	en_US
dc.subject	N-acetylated chitooligosaccharides	en_US
dc.subject	Comet assay	en_US
dc.subject	Oxidative DNA damage	en_US
dc.subject	Oxidative stress	en_US
dc.subject	Reactive oxygen species	en_US
dc.title	Comparative studies on ability of N-acetylated chitooligosaccharides to scavenge reactive oxygen species and protect DNA from oxidative damage	en_US
dc.type	Article	en_US
Appears in Collections:	IJBT Vol.14(2) [April 2015]

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