Burn wound healing potential of <i style="mso-bidi-font-style:normal">Plain gritha</i>, <i style="mso-bidi-font-style:normal">Shatadhauta ghrita</i> and <i style="mso-bidi-font-style:normal">Sahasradhauta ghrita</i> on wistar albino rats

Abstract

<span style="mso-bidi-font-style:italic" lang="EN-GB">The cow <i style="mso-bidi-font-style: normal">ghee</i><span style="mso-bidi-font-style: italic" lang="EN-GB"> is commonly used in India for the treatment of burns and wounds. The <i>ghee</i> based formulation were useful for wounds, painful ulcers, insect bite wounds, herpes, leprosy, wounds caused by heat or fire and deep wounds by external application as per the classical texts of <i>Ayurveda</i>. <span style="mso-bidi-font-style:italic">The present study was carried out to evaluate the efficacy of three processed cow <i style="mso-bidi-font-style: normal">ghee</i><span style="mso-bidi-font-style:italic"> in <span style="mso-bidi-font-weight:bold">burn wound healing. Partial thickness burn wounds were inflicted upon 5 groups of 6 rats each. Group I served as control (No treatment), Group II- silver sulfadiazine ointment treated group served as reference standard, Group III- <i>Plain gritha </i>(PG), group IV- <i>Shatadhouta ghrita</i> (SDG) and Group V-<i>Sahasradhouta ghrita</i> (SHDG)<span style="mso-bidi-font-weight:bold">. All drugs were applied topically on the burn wounds for 28 days or till complete healing. The parameters observed were epithelisation period and percentage of wound contraction. The results were analysed using one way ANOVA followed by Dunnet’s multiple‘t’ test. Epithelisation was hastened in all drug treated groups as compared to control group. The results of <i>Plain ghrita</i> and <i>Shatadhouta ghrita</i> treated groups were comparable to that of the standard treatment drug silver sulfadiazine and found statistically significant in comparison to normal control group. <i>Plain ghrita</i> and <i>Shatadhouta gritha</i> has burn wound healing potential comparable to silver sulfadiazine. Based on the analysis of the results it can be suggested that burn wound management can be initiated with <i>Shatadhouta ghrita</i> as the base for the formulation and mid way the management may be switched on to <i>Plain ghrita</i> based formulation. Further scientific investigation is required to provide basis for their efficacy and therapeutic claim.

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