Network Ethnopharmacology Approaches for Formulation discovery

Abstract

<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-US">Lifestyle disorders like obesity, diabetes, cardiovascular diseases, and cancers are difficult to manage using one drug-one target approach and so require a multi-targeted approach. <span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-in;="" mso-bidi-language:ar-sa"="" lang="EN-US">Any drug-whether chemical, botanical or biological-will have inherent limitations if it is focused only on a single target when<span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-US"> dealing with polygenic syndromes. A new branch known as network pharmacology which integrates systems biology and computational biology has emerged to study drug interactions with multiple targets. Several traditional multi-botanical formulations are widely used globally; however, their rationale and scientific evidence for pharmacodynamic actions remain insufficient. A systematic study of network ethnopharmacology- network pharmacology of medicinal botanicals- is considered as promising approach to understand the scientific basis of intelligent formulations which would facilitate transition from single target based drug discovery to multi-target based rational formulation discovery.This article briefly describesnetwork pharmacology and demonstrates the <i>Rasayana</i> property of <i>Triphala</i>in the light of this emerging technique.</span></span></span>