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http://nopr.niscpr.res.in/handle/123456789/34220| Title: | Catalyst and solvent free one-pot microwave synthesis of fused pyrimidine diones and triones |
| Authors: | Sontakke, Madhuri M Dhonde, Madhukar G Bhaskar, Chandrakant S Berad, Baliram N |
| Keywords: | Barbituric acids;Aldehydes;Carbamides;Thiocarbamides;Cyclodehydration reaction;Microwave synthesis |
| Issue Date: | May-2016 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | One pot three components synthesis of fused pyrimidine diones and triones have been achieved by reaction of barbituric acids, aldehydes and monosubstitued carbamides or thiocarbamides under microwave irradiation. The mild reaction conditions, easy product work-up, and good to high yields are some of the highlight of the present protocol. The method is applicable to the synthesis of variously substituted fused pyrimidine diones and thiones. This method offers substantial improvements in the reaction rates and yields, and also avoids the use of hazardous solvent and catalyst apart from applicability to the wide variety of substrates. |
| Page(s): | 629-636 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.55B(05) [May 2016] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 55B(5) 629-636.pdf | 162.17 kB | Adobe PDF | View/Open |
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