<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-US">Anti-urolithiatic activity of hydrogenated naphthol isolated from <i>Aerva lanata</i> (L.) Juss. flower extract</span>

Abstract

<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-US">One new hydrogenated naphthol was isolated for the first time from methanolic extract of <i style="mso-bidi-font-style:normal">Aerva lanata</i> (L.) Juss. flowers. The compound was elucidated as (2S.3R) 3-(3-hydroxy-3-methyl pent-4-en-1-yl)-2, 5, 5, 8a tetra-methyl-decahydronaphthalene-2-ol. The isolated compound (PC) was screened for anti-urolithiatic activity by ethylene glycol induced urolithiasis in rats. In the present study rats treated with the isolated compound (PC), reported for the first time from this taxon, reduced the deposition of calcium oxalate crystals by increasing their solubility and restoring the normal renal architecture.</span>