<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">Evidence of the nephroprotective effect of <i style="mso-bidi-font-style:normal">Carica papaya</i> L. leaves in streptozotocin-induced diabetic rats</span>

Abstract

<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";background:white;mso-ansi-language:en-gb;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">Protection against diabetic nephropathy (DN) is one of the main targets in diabetes treatment and present study evaluates the nephroprotective effect of <i style="mso-bidi-font-style: normal">Carica papaya</i><span style="mso-bidi-font-style:italic"> L. in streptozotocin (STZ) induced diabetic rats. DN rats were treated with 1.5 and 2.5 gm/dl <i>C. papaya </i>leaf extract for 6 weeks to determine its nephroprotective effect with different parameters. Pimagedine (1 ml/mg) served as a reference drug. Compared to diabetic control group, <i>C. papaya</i> (1.5 and 2.5 gm/dl) treatment significantly decreased some important parameters including plasma glucose, HbA1-c, <span style="font-size: 11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">urinary AER and albumin/creatinine ratio. Improvement in GFR was also significant by <i>C. papaya</i>. However, the decrease in blood urea nitrogen (BUN), plasma creatinine, blood pressure (B.P), total cholesterol and serum albumin levels were significant only in diabetic group treated with 2.5 gm/dl of <i>C. papaya</i> leaf extract. Serum triglyceride and urine volume decreased with both low and high doses of <i>C. papaya</i>. Histological examination revealed marked improvement in glomerular morphology after <i>C. papaya </i>treatment. The study concludes that <i>C. papaya</i> leaf extract may exert ameliorative effect on DN.</span></span></span>