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dc.contributor.authorSilig, Yavuz-
dc.contributor.authorCetinkaya, Oge-
dc.contributor.authorDemirezer, L Omur-
dc.description.abstractThe effect of aqueous extract from the roots of Rumex patientia L. (Polygonaceae) (D-1), a traditional Turkish medicine used as a laxative and cholagogue, on drug-metabolizing enzymes, such as cytochrome P4502E1, NADPH cytochrome c reductase, NADH cytochrome b5 reductase and glutathione-S-transferase (GST); and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were studied in male Wistar albino rat liver. A significant increase was observed in cytochrome P4502E1 and GST activities, but not in NADPH-cytochrome c reductase and NADH-cytochrome b5 reductase activities. Serum AST and ALT activities were found within the normal laboratory range values. The results demonstrated that the aqueous extract of R. patientia triggers induction of cytochrome P4502E1 in liver and cytosolic GST activity.en_US
dc.sourceIJBB Vol. 41(1) [February 2004]en_US
dc.subjectRumex patientiaen_US
dc.subjectDrug-metabolizing enzymesen_US
dc.subjectCyto-chrome P4502E1en_US
dc.subjectNADPH-cytochrome c reductaseen_US
dc.subjectNADH-cytochrome b5 reductaseen_US
dc.titleEffects of Rumex patientia L. extract on some drug-metabolizing enzymes in rat liveren_US
Appears in Collections:IJBB Vol.41(1) [February 2004]

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