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http://nopr.niscpr.res.in/handle/123456789/37016| Title: | Cytotoxicity effect of Capparis spinosa L. on the HepG2 human hepatocellular carcinoma cell line |
| Authors: | Sheikh, Masoud Eshraghi, Hamid Reza Khoshnia, Masoud Mazandarani, Masoumeh Moradi, Abdolvahab |
| Keywords: | Hepatocellular carcinoma;Capparis spinosa L.;Cell proliferation;Apoptosis;Cell cycle |
| Issue Date: | Jan-2017 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A01D 4/04, C12M, C12N, C12Q, B0, A61K 36/00 |
| Abstract: | Hepatocellular carcinoma (HCC) is a complex condition associated with a poor prognosis. HCC is the third most common cause of cancer mortality which is continuously increasing. Capparis spinosa is used by traditional medical physicians in Iran to treat liver disorders and has been shown to prevent HCC. Treatment of HepG2 cells with Capparis spinosa ethanolic extract (CSE) inhibited cell proliferation in a dose dependent manner, and enhanced apoptosis of HepG2 cells by activation of caspase-8 and caspase-9 and down regulation of Bcl-2. Treatment of HepG2 cells with CSE also increased expression of the Cdk inhibitory protein (Cip1/p21). This study is a new design to investigate the in vitro effect of CSE on anti-HCC property. |
| Page(s): | 73-77 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Appears in Collections: | IJTK Vol.16(1) [January 2017] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJTK 16(1) 73-77.pdf | 143.29 kB | Adobe PDF | View/Open |
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