Optimization of <i>Parisheka kriyakalpa</i> (procedure for closed eye irrigation) 3: A clinical study on acute conjunctivitis with <i>Triphala</i> decoction

Abstract

Scientific validation of any drug, therapy, protocol or procedure requires a standardized procedure of manufacturing process, execution of the protocol or therapeutic procedure for standardization if the formulation protocol or procedure has variables in literature and practice; they need to be optimized first following a systematic approach with prospective clinical application for further validation of the optimized data. <i>Netra Parisheka/Seka</i> foremost topical ocular therapeutic procedure had similar prevalence of variability in literature and practice. To meet the above criteria and to achieve the objective of standardization; optimization of SOP of <i>Netra Parisheka</i> procedure was thought to be the pre-requisite. Using all adopted parameters, total 51 (68 eyes) patients were enrolled out of which 50 (67 eyes) patients completed the study. Highly significant result with P value > 0.001 of <i>Netra Parisheka</i> procedure for a period of four days in dose of 750 ml, 500 ml & 250 ml for <i>Vata, Pitta</i> & <i>Kaphaja Netra roga,</i> respectively, temperature 37.2–37.7 ^oC, height 6-6.5 cm, duration 5–15 min, width 1.5-2.0 mm in <i>Aamavastha</i> of <i>Netra roga </i> (acute inflammatory condition of the eye) and shows its definite role of the procedure in the conversion of <i>Aamavastha</i> to <i>Niraamavastha</i> (remission of acute inflammatory sign) after 4^th day. In some cases complete remission of symptoms was observed, i.e., 40%, while more than 70 % patients were having improvement in their signs and symptoms.