Nitrogen doped graphene supported Pt-Pd nanoparticle modified GC electrode for electrochemical determination of tramadol and paracetamol

Abstract

The role of functionalized nitrogen doped graphene (NGp) using poly(diallyldimethylammonium chloride) (PDDA) as modified electrode has been discussed. Pt-Pd bimetallic nanoparticles have been anchored on PDDA-NGp to form PtPd-PDDA-NGp nanocomposites, which are characterized by high resolution transmission electron microscope, X-ray diffraction and Raman spectroscopy. The simultaneous determination of paracetamol and tramadol has been carried out using the nitrogen doped graphene supported Pt-Pd nanoparticle modified glassy carbon electrode in 0.1 <i>M</i> Britton-Robinson buffer solution (pH 5.0). Two well-defined voltammetric peaks are obtained in square wave voltammogram measurements. It has been observed that the modified electrode can detect a wide linear range of concentrations of paracetamol from 5×10^-6 to 1×10^-4 <i>M</i>, and tramadol from 1.2×10^-5 to 2.4×10^-4 <i>M</i>. The limit of detection was found to be 1.8×10^-7 and 5.7×10^-6 <i>M</i> for paracetamol and tramadol, respectively (<i>S/N</i> = 3).