Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/404| Title: | Asymmetric synthesis of (R)-(–)-baclofen via asymmetric dihydroxylation |
| Authors: | Thakur, V V Paraskar, A S Sudalai, A |
| Keywords: | Asymmetric dihydroxylation;Baclofen;ϒ-aminobutyric acid;Parkinsons’ disease;Cyclic sulfate |
| Issue Date: | Feb-2007 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.⁸ C07C |
| Abstract: | A short and efficient asymmetric synthesis of (R)-(–)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of ⍺,β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule. |
| Page(s): | 326-330 |
| ISSN: | 0367-4699 |
| Appears in Collections: | IJC-B Vol.46B(02) [February 2007] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 46B(2) (2007) 326-330.pdf | 63.46 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.