Synthesis, characterization and antimicrobial activity of some 2,4-dibromo-1,5-dimorpholino/dipiperidino-pentane-3-ones

Abstract

Condensation of acetone (<b>2</b>) with appropriate arylaldehydes (<b>1</b>) in the presence of ethanolic NaOH solution afforded 1,5-diarylpenta-1,4-diene-3-ones (<b>3</b>) which were subjected to bromination under controlled conditions to give 1,2,4,5-tetrabromo-1,5-diarylpentan-3-ones (<b>4</b>). Treatment of (<b>4</b>) with NH-heterocyclic base such as morpholine / piperidine in dry THF afforded the title compound in moderate yield. All the newly synthesized compounds were characterized on the basis of their spectral (IR, ¹H NMR, MS) and analytical data. Some of the newly synthesized compounds showed moderate to high antimicrobial activity.