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http://nopr.niscpr.res.in/handle/123456789/40835| Title: | Kinetic and theoretical studies on the reaction of phenacyl bromide with 4DMAP in the presence of certain phenols |
| Authors: | Pillay, M Krishna Jeyaraman, R Nallu, M Venuvanalingam, P Ramalingam, M |
| Issue Date: | May-1997 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The quanternization reaction between phenacyl bromide an 4-(dimethylamino)pyridine (4DMAP) has been studied at 25, 30 and 35°C in acetone, Added phenols with pKa > 7.0 retard the rate of quaternization and there is no ether formation. This has been confirmed through product analysis by HPLC using paired ion chromatography (PIC) reagents –A. The reaction has been followed conductometrically using Gugenheim’s method. Theoretical calculations(PM3) confirm the formation of H-bonded complex between the phenoI(s) and 4DMAP, that could retard the rate of quaternization. Relative proton affinity (PA) values of various phenolates computed here explain the preferential formation of quaternary salt over ether in the reaction. |
| Page(s): | 414-417 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.36A(05) [May 1997] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 36A(5) 414-417.pdf | 126.15 kB | Adobe PDF | View/Open |
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