Transfer Gibbs energies of some DNA/ RNA bases in some aqueous electrolyte solutions- A thermochemical clue to a possible antidote for the replication of cancerous cells

Abstract

Transfer Gibbs energies (<img src='/image/spc_char/delta.gif' border=0><i>G</i><img src='http://www.niscair.res.in/jinfo/equation30.gif' border=0>) of uracil, thymine, cytosine and adenine from water .to some aqueous electrolyte solutions have been determined at 25°C from solubility measurements. The observed increase in <img src='/image/spc_char/delta.gif' border=0><i>G</i><img src='http://www.niscair.res.in/jinfo/equation30.gif' border=0> values and the accompanying destability of these bases linking the double stranded helices of DNA/RNA molecules, are proposed to act as a thermochemical clue for a possible antidote for the replication of cells and possibly cancerous cells as well.