Synthesis, structural characterization and biological screening of manganese(Il) complexes of S/O and N donor agents

Abstract

Manganese(1I) complexes of biologically potent ligands hydrazinecarboxamide (HSCZ) or -carbothioamide (HTSCZ) have been prepared. These are of the type [MnCI(N͡x)H₂O] and [Mn(N͡X₂] (X is O or S and N͡X = donor system). Elemental analyses. molecular weight determinations. molar conductance. magnetic moment. electronic. IR and ESR spectral studies have been employed to characterize these complexes. Magnetic data show that the ground state of these compounds is the expected high spin state and the spectral data suggest that the coordination of the ligand to the central metal atom takes place in a monobasic bidentate fashion through the thiolo sulphur or hydroxo oxygen and azomethine nitrogen. The representative free ligands and their respective metal complexes were tested in vitro against different microorganisms to assess their antimicrobial properties.