Effects of inorganic salts on rate of alkaline hydrolysis of <i>N</i>-phthaloylglycine: Kinetic evidence for the ion-pair formation

Abstract

The effects of [LiCI], [NaCI], [Na₂CO₃], [KCI], and [BaCl₂] on the rate of reaction of hydroxide ion with anionic N-phthaloylglycine (S^-) at 30&deg;C and in an aqueous solvent containing 2% v/v CH₃CN reveal a nonlinear increase in pseudo-first order rate constants (k_obs) with increase in [salt]. The observed data are explained in terms of a mechanism involving ion-pair formation between S^- and cations of the salts. The association constants for ion-pair formation are highly sensitive to the valence state of cations and almost insensitive to the valence state of anions of the salts.