Synthesis, characterization and in vitro antitumor activities of binary and heterobimetallic complexes of oxovanadium(IV), manganese(II), iron(II,III), cobalt(II,III), nickel(II), copper(II) & zinc(II) with <i>p</i> -hydroxy dithiobenzoate

Abstract

A few complexes of the types M (<em>p </em>&ndash;Ohdtb)₂ [M=Mn(II), Cu(II) or Zn(II)], M(<em>p</em> -OHdtb)₃ [M=Fe(Ill) or co(III)], V(p-OHdtb)₄ and Ni(<em>p</em>-OHdtbS) (p-OHdtb = <em>p</em> hydroxy dithiobenzoate] and heterobimetallic complexes M[Cd(<em>p</em> -OHdtb)₄] [M=VO²⁺, Mn(II), Fe(II), Co(II), Ni(II) or Zn(II) have been prepared in water ethanol medium. The complexes have been characterized by elemental analyses, magnetic susceptibility measurements, and UV-VIS, IR, ESR and NMR (¹H and ^!3C) spectral studies. In vitro results of the binary complexes on P-815 (murine mastocytoma) indicate that the complexes show significant inhibition on ³H-thymidine and ³H-uridine incorporation in tumor cells and thus inhibit DNA and RNA replications.