Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat

Abstract

Ferric nitrilotriacetic acid (Fe-NTA) (9 mg Fe/kg body weight, ip) caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in renal lipidperoxidation, serum toxicity markers viz. creatinine, blood urea nitrogen, hydrogen peroxide generation, ornithine decarboxylase activity and [³H] thymidine incorporation into renal DNA in wistar rats. However, pretreatment of animals with luteolin (10 and 20 µmol/kg body weight) for 7 consecutive days resulted in significant decrease in above parameters level. Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant level. The enhanced reduced glutathione level and enzyme activities involved in xenobiotic metabolism and maintaining antioxidant status of cells is suggestive of a chemopreventive efficacy of luteolin against Fe-NTA mediated oxidative stress, toxicity and cell proliferation response in rats.