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http://nopr.niscpr.res.in/handle/123456789/42199| Title: | Metal ion interactions with antibiotic drugs: Part III-Complex formation of copper(II) with ampicillin |
| Authors: | Mukherjee, G N |
| Issue Date: | Dec-1991 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Combined pH-metric and spectrophotometric study on the complex formation of Cu2+ with ampicillin, α-d-( - )aminobenzylpenicilln, ampH±, at 37°C in aqueous medium at a fixed ionic strength, l= 0.1 M NaNO3, indicates formation of complexes of the types: Cu(amp)+, Cu(amp)2 Cu(H-1 amp), Cu(H-1 amp)(amp)- and Cu(H-1 amp) . Proton-ligand and metal-ligand constants are found to be: pK 2.50; pK , 7.05; pK (calc.), 13.37; log K (amp), 4.79; log K(amp)2, 7.70; pK (amp), 8.50; pK(amp)2, 9.81; pK(amp)(H-1,amp)(amp) 10.31; log β(H-1,amp), -3.71; log β(H-1,amp)(amp), - 2.11; log β(H-1,amp)2, -12.42 and log K(H-1,amp)+(amp), - 22.08 ± 0.05. Ambidentate nature of the ligand and its possible modes of coordination with the Cu2 + at different pH values have been elucidated on the basis of electronic spectral measurements. |
| Page(s): | 1033-1037 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.30A(12) [December 1991] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 30A(12) 1033-1037.pdf | 969.56 kB | Adobe PDF | View/Open |
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