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Title: Safety evaluation of Aloe vera pulp aqueous extract based on histoarchitectural and biochemical alterations in mice
Authors: Bala, Shashi
Chugh, Neha Arora
Bansal, Subhash Chand
Garg, Mohan Lal
Koul, Ashwani
Keywords: Cosmetics;Herbal;Histopathology;Lactate dehydrogenase;Lipid peroxidation;Nutraceuticals
Issue Date: Aug-2017
Publisher: NISCAIR-CSIR, India
Abstract: Aloe vera has a long history as a popular herbal remedy. A scrutiny of literature reveals that it possesses beneficial as well as harmful effects, thus making it essential to assess its toxicity profile before employing it as a medicinal agent. Various authors have reported conflicting observations on different applications of Aloe vera in experimental animals. Qualitative phytochemical analysis of Aloe vera extract used in the present study revealed the presence of tannins, carbohydrates and anthraquinone glycosides. For assessing the toxicity profile, Balb/c mice were divided into four groups— control and Aloe vera treated @ 250, 100 and 50 mg/kg body weight, and were administered with respective doses for 30 days. Histopathological examination of various tissues revealed significant structural alterations on administration of higher doses of Aloe vera indicating the toxicity, which was also associated with enhanced peroxidative damage and serum LDH activity. Low dose of Aloe vera revealed normal histoarchitecture of various tissues along with biochemical parameters studied. Considering these results 50 mg/kg body weight Aloe vera extract is considered safe and shall be employed for further studies.
Page(s): 568-575
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.55(08) [August 2017]

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