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Title: Immunomodulatory effect of leaf extracts of Barringtonia acutangula (L.) Gaertn.
Authors: Rashmi, K
Hegde, Karunakar
Shenoy, K Bhasker
Keywords: Barringtonia acutangula;Cyclophosphamide;HA titre;Immunomodulation;Vit. E
Issue Date: Oct-2017
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K, A61K 31/00, C07D 311/92, A61K 39/00, G01N 33/53
Abstract: The presence of immunostimulant compounds in higher plants has been extensively reviewed but only a limited number of immunomodulatory products of plant origin have been reported. The present investigation was designed to get an in depth understanding of the efficacy of crude extracts of leaf of Barringtonia acutangula as immunomodulatory agent on experimental rats. The oral administration of aqueous and methanolic leaf extracts (LWBA and LMBA) of B. acutangula for 14 days was found to stimulate the non specific arm of immunity. Haemagglutinating antibody (HA) titre test was performed to know humoral antibody response of LWBA and LMBA extracts at 200 mg/kg and 400 mg/kg doses. Results obtained showed significant (p < 0.001) increase in antibody production in response to sheep red blood cells (SRBCs) at both doses when compared with Cyclophosphamide treated control group. Cyclophosphamide induced suppression of humoral immune response was significantly attenuated by daily oral treatment of LWBA and LMBA extracts at a dose of 400 mg/kg. LWBA extract showed slightly more HA titre than LMBA extract. The results justify that the LWBA and LMBA extracts of B. acutangula have a strong potential to be explored further as an immune-based herbal therapy.
Page(s): 689-693
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.16(4) [October 2017]

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