Serum enzymes activity and liver histopathological changes of lactating mice treated with <em>Eurycoma longifolia </em>Jack. roots

Abstract

<em>Eurycoma</em> <em>longifolia</em> Jack. (<em>pasak bumi</em>) is a species that has been used as a traditional medicine. The aim of this research is to evaluate the adminstration effect of <em>pasak bumi</em> roots on liver lactating mice. Each mice was administered roots of <em>pasak bumi</em> methanol-water fraction at dose 14 mg/20 g mice body weight for 7 consecutive days. Positive control group received Curcuma at dose 0.16 mg/20 g mice body weight and negative control (placebo) group received 0.06 mL/20 g mice body weight of aquadest daily for 7 consecutive days. Compared to aquadest and Curcuma, the administration of <em>pasak bumi</em> slightly increase alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (p &lt; 0.05). However, histopathological studies shown congestive and mild degree of fatty change after the administration of aquadest, roots of pasak bumi methanol-water fraction, and Curcuma. It is concluded that the administration of roots of <em>pasak bumi</em> methanol-water fraction to lactating mice could not decrease the liver function.