Protective effect of standardized extract of <em>Glycine max</em> seeds against experimentally induced gastroesophageal reflux disease in rats

Abstract

Gastroesophageal reflux disease (GERD) is a condition in which the stomach contents flow upward into the oesophagus. The molecules having flavonoid like structure reported to have radical scavenging activity and the antioxidant activity are useful in the treatment of GERD. Kaempferol is one such flavonoid found in plants including soybean. In the current study, we investigated the effect of standardized extract of <em>Glycine max</em> (soybean) seeds on gastroesophageal reflux disease in rats. The standardized extract (50-200 mg/kg) was administered orally twice daily for 5 days and omeprazole 1 h prior to the induction of gastroesophageal reflux disease. The levels of gastric wall mucus increased and of plasma histamine and H⁺-K⁺-ATPase significantly decreased in groups treated by standardized extract. The standardized extract reduced lipid peroxidation and superoxide dismutase and increased the levels of catalase and reduced glutathione. The results suggest that the <em>Glycine max </em> seeds are effective against gastroesophageal reflux disease and it protects esophageal in rats.