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dc.contributor.authorGuha, Debjani-
dc.contributor.authorShen, Chengli-
dc.contributor.authorGupta, Phalguni-
dc.contributor.authorChakraborty, Rohini Nandan-
dc.contributor.authorChatterjee, Ramdas-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractSexually transmitted infection (STI) is a major public health problem in human immunodeficiency virus (HIV)-infected individuals. This study evaluated the effect of STIs, such as herpes simplex virus type-2 (HSV-2) and Chlamydia trachomatis (CT) on human papillomavirus (HPV) copy number and associated cervical cytological abnormalities in context of HIV infection. Cervical cells from 74 HIVseropositive and 50 seronegative women were examined for HPV, HSV-2 and CT DNA by PCR. HIVinfected women had higher HSV-2 (P =0.002) and HPV infection (P=0.001) in cervix. HPV 16 was detected as the most predominant genotype. Combination of HIV and other STIs (HSV-2 and CT) was associated with higher HPV prevalence in cervix (P <0.01). Cervical HPV viral load (VL) was increased in HIVinfected subjects co-infected with STIs compared to those with only HPV infection (P=0.008). Women with abnormal cervical cytology had higher HPV copy number/cell compared to those with normal cytology (P <0.001). In conclusion, STIs may not have direct effect on cervical cytological abnormalities, they increase HPV VL that in turn worsen cervical cytological complications in HIVinfected women. Therefore, screening of STIs in HIVinfected high-risk Indian women may be important to evaluate HPV burden and abnormal cervical dysplasia.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.56(05) [May 2018]en_US
dc.subjectChlamydia trachomatis (CT)en_US
dc.subjectHerpes simplex virus type-2 (HSV-2)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectHuman papillomavirus (HPV)en_US
dc.subjectViral loaden_US
dc.titleHigh HPV load and sexually transmitted infections increase the risk of abnormal cervical cytology in HIVinfected women in Indiaen_US
Appears in Collections:IJEB Vol.56(05) [May 2018]

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