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http://nopr.niscpr.res.in/handle/123456789/44634| Title: | A new antibacterial imidazole from the marine sponge Iricinia fusca |
| Authors: | Meesala, Srinu Singh, Ruby Watve, Milind G Naik, Dattatraya G. |
| Keywords: | Anticancer activity;Antimicrobial;Imidazole alkaloids;Mass spectrometry;NMR;Sponge |
| Issue Date: | Mar-2018 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2015.01)−A01N 63/00, CO7D 403/14 |
| Abstract: | A new imidazole alkaloid (1) along with two known compounds, variabilin (2) and iricinialactam A (3) have been isolated from the Arabian marine sponge Ircinia fusca. The structure of the new compound was established as 4-((1, 2-dihydroxy-5-(methyl (1-methyl-1H-imidazol-4-yl) amino) pentan-3-yl) oxy)-3, 5-dimethoxy-1-methylpyrrolidin-2-one (1) by 1D and 2D NMR, and high-resolution electrospray ionization mass spectrometry (HRESIMS). Compound 1 exhibited selective growth inhibitory activity against gram-positive bacteria S. aureus at 100 µg/mL. |
| Page(s): | 75-78 |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Appears in Collections: | IJNPR Vol.9(1) [March 2018] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJNPR 9(1) 75-78.pdf | Main Article | 464.61 kB | Adobe PDF | View/Open |
| IJNPR 9(1) 75-78_Suppl Data.pdf | Supplementary Data | 1.1 MB | Adobe PDF | View/Open |
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