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Title: Synthesis, characterization, anti inflammatory activity and molecular docking study of novel pyrazoline derivatives bearing chalcone backbone
Authors: Bhadoriya, Upendra
Jain, Dinesh Kumar
Keywords: Synthesis;Chalcone;Heterocycles;Pyrazoline;Claisen-Schmidt condensation;Anti-inflammatory
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
Abstract: Novel pyrazoline derivatives incorporating chalcone backbone have been synthesized, characterized and evaluated for their anti-inflammatory activity. The structural features of synthesized compounds have been established using IR, 1H NMR, mass spectroscopy and elemental analysis. In vivo anti-inflammatory activity has been measured using carrageenan induced paw edema method. Molecular docking study of synthesized compounds has also been performed using cyclooxygenase-2 (COX-II) receptor PDB ID: 4-COX. Some of the synthesized compound show remarkable anti-inflammatory potential. The compound (E)-1-(5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydropyrazol-1-yl)-3 (4methoxyphenyl)prop-2-en-1-one 6h shows potent anti-inflammatory activity. The outcome of docking studies also support results of in vivo anti-inflammatory activity.
Page(s): 1315-1321
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(10) [October 2018]

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