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http://nopr.niscpr.res.in/handle/123456789/4567| Title: | Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats |
| Authors: | Medhi, B Prakash, A Avti, P K Saikia, U N Pandhi, P Khanduja, K L |
| Keywords: | Antioxidant defense system;Monuka honey;Sulfasalazine;Ulcerative colitis |
| Issue Date: | Aug-2008 |
| Publisher: | CSIR |
| Abstract: | Manuka honey (MH, 5g/kg) provided protection against trinitro-benzo-sulphonic acid induced colonic damage. Combination therapy (MH+sulfasalazine) also reduced colonic inflammation and all the biochemical parameters were significant compared to control and MH alone treated group. Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant parameters. Morphological and histological scores were significantly reduced in combination groups. In inflammatory model of colitis, oral administration of MH (5g/kg) and combination with sulfasalazine (360 mg/kg) with MH (5g/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of Manuka honey with sulfasalazine in colitis. |
| Page(s): | 583-590 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.46(08) [August 2008] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 46(8) 583-590.pdf | 669.86 kB | Adobe PDF | View/Open |
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