Effect of<i style=""> Commiphora mukul</i> extract on cardiac dysfunction and ventricular function in isoproterenol-induced myocardial infarction

Abstract

In present study, hydroalcoholic extract of <i>C. mukul</i> significantly improved the cardiac function and prevented myocardial ischemic impairment manifested in the form of increased heart rate, decreased arterial pressure, increased left ventricular end diastolic pressure, and altered myocardial contractility indices. <i>C. mukul</i> treatment additionally also produced a significant increase in lactate dehydrogenase levels and prevented decline of protein content in heart<i>. C. mukul</i> preserved the structural integrity of myocardium. Reduced leakage of myocyte enzyme lactate dehydrogenase and maintenance of structural integrity of myocardium along with favorable modulation of cardiac function and improved cardiac performance indicate the salvage of myocardium with <i>C. mukul</i> treatment. Guggulsterones which are considered to be responsible for most of the therapeutic properties of <i>C. mukul</i> may underlie the observed cardioprotective effect of <i>C. mukul</i> against cardiac dysfunction in isoproterenol-induced ischemic rats.