Synthesis, characterization and cytotoxicity of (3,4-diaminobenzoic acid)- haloplatinum(II)/palladium(II)

Abstract

The synthesis of platinum compounds of the type [Pt (daba) X₂](where daba = 3,4-diaminobenzoic acid and X = Cl, Br, or I) and the analogous chloro and bromo compounds of Pd(II) has been carried out. These compounds have been characterized by molar conductance measurements, electronic absorption, and infrared, ¹H NMR and X-ray photoelectron spectroscopy. The complexes are non-electrolytic in nature and have square planar geometry with two coordination positions occupied by two amino groups of 3,4- diaminobenzoic acid and remaining two positions occupied by halide ions. The sodium salts of the above compounds have been tested against P388 lymphocytic leukemia cells. [Pt(daba)Cl₂] and Pt(daba)Br₂l have I.D.₅₀ ovalues less than that of <em>cis</em>platin and [Pt(daba)I₂] has I.D₅₀ values comparable to that of <em>cis</em>platin.