Liquid membrane phenomena in the multiple actions of psychotropic drugs

Abstract

Multiplicity of biological actions of surface active psychotropic drugs has been discussed in the light of modifications in the permeability of relevant neurotransmitter molecules viz. dopamine, noradrenaline, adrenaline, γ-aminobutyric acid (GABA) and serotonin through the liquid membranes generated by these drugs. It has been shown that modification in the transport of relevant permeants through the drug liquid membranes likely to be generated at various sites of action may provide a generalized explanation for multiple actions of the surface active drugs. The drugs chosen for the present discussion are, haloperiodol, chlorpromazine, reserpine and imipramine. The data published earlier on the transport of relevant permeants through the liquid membranes generated by these drugs have been utilised for the present discussion.