Synthesis, characterization and biological activity of Cu(II) chelates with some acid derivatives

Abstract

The complexing behaviour of seventeen amino acid derivatives towards Cu(II) has been studied. Complexes of the types Cu(RH). xH₂O, Cu(RH). Cu(OH)₂. xH₂O [RH₃ = aspartic and glutamic acid derivatives, x = 0 - 4] and Cu(R’H)₂. yH₂O [R'H₂ = mono-basic amino acid derivatives and y = 0 - 2] have been prepared and characterized by IR, ESR, electronic spectral, magnetic moment and analytical data. On the basis of differences and direction of the shifts in the IR frequencies of v_as OCO and v_s OCO modes and ESR spectra, bonding odes of carboxylate group have been established. Biological activity of the complexes is more than that of the free metal ion and the ligands.