Synthesis, characterization and biological studies of palladium(II) complexes of some ON and NS donors

Abstract

The complexes of Pd(II) chloride with 5-aminouracil (AUH), 4-aminoantipyrine (AAPy), 4-nitrosoantipyrine (NAPy),2-aminobenzenethioi (ABTH) and dyes derived from β-naphthol and AUH (UANOLH₂), AAPy(APyANOLH) or ABTH (BTANOLH₂) have been prepared and studied. On the basis of elemental analyses, molar, conductance, IR and electronic spectral data, they have been characterized as PdL₂Cl₂ (L=AUH or NAPy), PdL'Cl₂(L' = AAPy) and PdL''Cl(L'' = ABT, APyANOL, BTANOLH or UANOLH). These complexes undergo complete decomposition above 215°C to form palladium oxide. The complexes have been screened for their possible antitumour activity <em>in vitro </em>using Dalton's Lymphoma Ascites (DLA) tumour cells.