Na⁺ K⁺-ATPase activity in response to exogenous dehydroepiandrosterone administration in aging rat brain

Abstract

Influence of exogenously administered dehydroepiand-rosterone (DHEA) on the activity of Na⁺K⁺ATPase was investigated in synaptosomal fraction from cerebral cortex, cerebellum, hippocampus and medulla regions of brain of 12 and 22 months old rats. DHEA was administered daily at the dose of 30 mg/kg/body wt, intraperitonially (ip) in both the age groups of rats for 1 month. Results showed that Na⁺K⁺ATPase activity, increased in DHEA treated rats in both the age groups. In terms of per cent increase, 22 months old animals showed significant increase in Na⁺K⁺ATPase activity in the synaptosomal fraction of all the four brain regions than in 12 months old DHEA-treated rats. This showed that exogenous DHEA modulated the activity of Na⁺K⁺ATPase and also protected the age-related loss of membrane integrity and functions. It was concluded that exogenous DHEA might be beneficial in terms of neuroprotection against age-related loss of Na⁺ K⁺ ATPase mediated brain functions like learning and memory.