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Title: Evaluation of antifungal efficacy of some medicinal plants on Candida spp. causing vulvovaginitis
Authors: Vidya, Anu G
Vijayan, Ajith
Jyothis, LJ
Nair, Reshmi
Suja, KP
Keywords: Bharangi;Black myrobalan;Clerodendrum serratum;Curcuma longa;Glorybower;Red creeper;Terminalia chebula;Turmeric;Ventilago maderaspatana
Issue Date: Apr-2019
Publisher: NISCAIR-CSIR, India
Abstract: The opportunistic yeast pathogen Candida albicans and the non albicans Candida spp. cause life threatening infections in patients leading to increased mortality rate. High toxicity of synthetic drugs on host tissues and multidrug resistance of organisms aggravates the problem. Medicinal plants are rich source of secondary metabolites with potential therapeutic effects. In this study, we tested ethanolic extracts of four different plants, namely Terminalia chebula, Ventilago maderaspatana, Clerodendrum serratum and Curcuma longa for their antifungal activity against three different Candida spp. The MIC value of T. chebula was 25 μg/mL and that of C. serratum was 50 μg/mL, whereas C. longa and V. maderaspatana showed activity at 12.5 μg/mL against C. albicans. The MIC values against C. tropicalis were reported as 50 μg/mL for T. chebula and V. maderaspatana, 25 μg/mL for C. longa and 100 μg/mL for C. serratum. In a similar way antifungal activity for C. glabrata were reported as 25 μg/mL for C. longa and T. chebula and finally 50 μg/mL for C. serratum and V. maderaspatana.
Page(s): 297-301
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.57(04) [April 2019]

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