A new antimicrobial pentacyclic triterpenoid from the rhizomes of Nardostachys jatamansi DC.

Abstract

Phytochemical investigation of <em>Nardostachys jatamansi </em>rhizomes has resulted in isolation of a new pentacyclic triterpenoid lup-20 (29)-en-3β-olyl-3β-<img src='http://www.niscair.res.in/jinfo/smaller.gif' border=0>-galactofuranosyl-6'-octadec-9''-enoate <strong>4</strong> along with three phytoconstituents characterized as 1-octadec-9',10'-dienoyl-2,3-<em>n</em>-dioctadecanoyl glycerol <strong>1</strong>, <em>n</em>-octanyl-<em>n</em>-octadecanoate <strong>2</strong>, <em>n</em>-nonyloctadecanoate <strong>3</strong>. The structures of all the isolated compounds have been elucidated on the basis of spectral data analysis such as IR, ¹H and ¹³C NMR, mass spectroscopy and chemical reactions. Compounds <strong>1, 2, 3</strong> have been reported first time from Nardostachys genus. The isolated phytoconstituents have been tested for antimicrobial activity against bacterial and fungal strains. Only compound <strong>4</strong> shows antimicrobial activity.