Antihyperuricemic activity of gum of Calophyllum inophyllum ultra high dilutions in potassium oxonate induced wister albino rats

Abstract

Hyperuricemia is a biochemical abnormality and it affects the quality of life. Many medicinal substances are used in lowering the uric acid. The study designed to find hypouricemic effects ofultrahigh dilutions, the gum of <em>Calophyllum inophyllum, Acid benzoicum </em>in oxonate of potassium induced hyperuricemic wistar albinomodel.<br> The experiment consist of 11 groups of albino rats. All the groups were treated with oxonate of potassium except normal control. Healthy group of animals received only distilled water, hyperuricemic control group were given alcohol mixed in distilled water. A standard allopathic medical substance Allopurinol and <em>Acid benzoicum</em> ultra high dilutions were given in time dependent manner (single dose/day) in different experimental groups. Blood samples were collected by rat tail vein bleeding. The uric acid and creatinine levels of serum were analyzed by using standard measuring kits. The Student's <em>t</em>-test was used for statistical analysis of difference between the groups <em>p</em> ≤ 0.05 was reflected significant.<br> Oral intake of <em>Acid benzoicum</em> ultrahigh dilutions reduceduric acid levels of hyperuricemic wistar albino rats in time dependent mode. At 3^rdday and 7^thday administration of <em>Acid benzoicum </em>ultrahigh dilutions decreased the level of uric acid more ominously as compared to one day administration. However, allopurinol a standard allopathic drug normalized the uric acid level in all experimental groups.<br> The current work showed significant hypouricemic effects of <em>Acid benzoicum</em> ultrahigh dilutions in hyperuricemic wistar albino model. However, clear conclusion of hypouricemic activity of <em>Acid benzoicum</em> needed repetition of experimental work.