Synthesis and bioactivity study of 2,5-bismercapto-1,3,4- thiadiazole heterocyclic derivatives

Abstract

A series of acylhydrazone compounds 3a-i and acylthiosemicarbazides 4a-h containing thiadiazole rings have been synthesized conveniently in high yields. Some heterocyclic derivatives 5 are prepared by the method of dehydration of compounds 4. Structure of all these compounds have been confirmed by elemental analysis, IR, ¹H and ¹³C NMR. The bioassay result indicates that some compounds have relatively low antibacterial activity and other compounds have bioactivity for improving plant growth.