Synthesis, free radical scavenging and α-glucosidase inhibitory activities of 2H-chromenylphenyloxazolones

Abstract

A series of 2<em>H</em>-chromenylphenyloxazolones have been prepared starting from 2<em>H</em>-chromene-3-carbaldehydes. The compounds have been evaluated for their DPPH, ABTS^.+ free radical scavenging and α-glucosidase inhibitory activities. Compound <strong>4g</strong> has been identified as the most potent ABTS^.+ free radical scavenger when compared to the standard drug. The compounds <strong>4k</strong>, <strong>5a-c</strong> and <strong>5g</strong> are identified as potent ABTS^.+ free radical scavengers in the present series of the compounds. Compound <strong>5g</strong> has been identified as a promising α-glucosidase inhibitor. Molecular modeling studies have been carried out for compound <strong>5g</strong> to explain the molecular basis of α-glucosidase inhibition.