Analytical techniques used to characterize drug-polyvinylpyrrolidone systems in solid and liquid states – An overview

Abstract

Homogeneous distribution of poorly water-soluble drugs in polyvinylpyrrolidone (PVP), a hydrophilic carrier, is definitely a suitable way to improve the bioavailability of such drugs. However, fundamental knowledge of drug polymer interaction and comprehensive study of the thermal, structural and solubility properties of such binary systems is the prerequisite for the development of useful drug product. The paper reviews physical state, dissolution behavior and elucidation of drug-PVP interaction in solid dispersion using XRD, FTIR, DSC, SEM, hot stage microscopy and NMR. The importance of suitable selection of the system preparation methods have also been demonstrated and emphasis is laid on the potential methods for the industrial production of solid dispersions.